Australians discover that an antiparasitic drug kills new virus in 48 hours
The drug called ivermectin that Australian scientists guarantee will eliminate the new coronavirus is produced by the Portuguese pharmaceutical company Hovione.
The new coronavirus can be fought with an antiparasitic
Paula Sá
Australian researchers say they have discovered that a drug called ivermectin, which is available worldwide and is produced by a Portuguese pharmaceutical company, can eliminate covid-19 in a single day in a single dose.
In a study led by the Biomedicine Discovery Institute (BDI) of Monash University in Melbourne (Australia), in conjunction with Peter Doherty Institute of Infection and Immunity (Doherty Institute), it was proven that in cell cultures the antiparasitic drug (used for example in the fight against to lice] kills the virus that is causing a worldwide pandemic.
"We found that even a single dose could eliminate all viral RNA within 48 hours and, furthermore, at 24 hours there is a really significant reduction," said the researchers, whose work was published in the journal Antiviral.
This drug, approved by several drug agencies, including the American one, also proved to be effective "in vitro", according to the researchers, against a wide range of viruses, including HIV, dengue, influenza and zika.
However, tests have not yet been performed on people.
"Ivermectin is widely used and is considered a safe drug.
We need to determine now whether the dose that can be used in humans will be effective, this is the next step.
Now, when we have a global pandemic and there is no approved treatment, if we had a compound that was already available worldwide, it could help people earlier. Realistically, it will take a while for a widely available vaccine to be applied, "say the researchers.
Medicine produced in
Portugal
Ivermectine is a deworming product produced by the Portuguese pharmaceutical company Hovione, according to Rádio Renascença, which heard the commercial director of the brand about the Australian discovery. Marco Gil expressed his caution regarding the study on this medicine, which has been widely known since the 1980s, since it was used to fight various diseases such as river blindness.
Speaking to RR, Marco Gil recalled all this baggage that Ivermectin has and that, in addition, it has already earned the Nobel Prize for two researchers for its application in Africa, saving thousands of people.Ivermectine is a deworming product produced by the Portuguese pharmaceutical company Hovione, according to Rádio Renascença, which heard the commercial director of the brand about the Australian discovery. Marco Gil expressed his caution regarding the study on this medicine, which has been widely known since the 1980s, since it was used to fight various diseases such as river blindness.
Still on the radio, Marco Gil recalled that "at this moment, phase three studies have to be carried out - already in patients - and the therapeutic dose will have to be discovered, in order to determine if, in fact, that dose is within the limits of toxicity with which this product can be used ", but recognizes that the fact of knowing the molecule for decades" speeds up the process ".
Although it has indicated a horizon of six to nine months to know the result of the medicine's effectiveness.
The Hovione official admitted limitations on the large-scale production of the drug in a short period of time.
"It depends on the quantities and the population to be treated and, of course, there will be limitations and an adaptation time to be able to increase production exponentially if necessary," he told RR.
Even so, Ivermectin does not have a patent, it is a generic and, therefore, large-scale production can be carried out in other countries and will not be expensive.
Marco Gil exaggerates expectations about the rapid administration of the drug, explaining that, while on the one hand Ivermectin "does not have relevant side effects, being safe to administer, it has been studied for many years, and from this point of view it brings the security of being a product with low toxicity ", on the other hand" will depend a lot on the therapeutic dose that will be necessary to administer to patients of Covid 19 "
Source:
https://www.dn.pt/vida-e-futuro/australianos-descobrem-que-um-medicamento-antiparasitario-mata-novo-virus-em-48-horas--12031543.html
Possible coronavirus drug identified by Monash University scientists
- Whilst shown to be effective in the lab environment, Ivermectin cannot be used in humans for COVID-19 until further testing and clinical trials have been completed to confirm the effectiveness of the drug at levels safe for human dosing.
- For any medical questions you have about your health, please consult your health care provider.
- The potential use of Ivermectin to combat COVID-19 remains unproven, and depends on pre-clinical testing and clinical trials to progress the work.
- A Monash University-led study has shown that an anti-parasitic drug already available around the world can kill the virus within 48 hours in cell culture.
- Scientists showed that a single dose of the drug, Ivermectin, could stop the SARS-CoV-2 virus growing in cell culture.
- The next steps are to determine the correct human dosage – ensuring the doses shown to effectively treat the virus in vitro are safe for humans.
- The use of Ivermectin to combat COVID-19 depends on pre-clinical testing and clinical trials, with funding urgently required to progress the work.
- Ivermectin is an FDA-approved anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.
- This Monash University-led collaborative study was published in Antiviral Research, a peer-reviewed medical journal published by Elsevier. Please see the study DOI here:
A collaborative study led by the Monash Biomedicine Discovery Institute (BDI) with the Peter Doherty Institute of Infection and Immunity (Doherty Institute), a joint venture of the University of Melbourne and Royal Melbourne Hospital, has shown that an anti-parasitic drug already available around the world kills the virus within 48 hours.
The Monash Biomedicine Discovery Institute’s Dr Kylie Wagstaff, who led the study, said the scientists showed that the drug, Ivermectin, stopped the SARS-CoV-2 virus growing in cell culture within 48 hours.
“We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it,” Dr Wagstaff said.
Ivermectin is an FDA-approved anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.
Dr Wagstaff cautioned that the tests conducted in the study were in vitro and that trials needed to be carried out in people.
The Monash Biomedicine Discovery Institute’s Dr Kylie Wagstaff, who led the study, said the scientists showed that the drug, Ivermectin, stopped the SARS-CoV-2 virus growing in cell culture within 48 hours.
“We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it,” Dr Wagstaff said.
Ivermectin is an FDA-approved anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.
Dr Wagstaff cautioned that the tests conducted in the study were in vitro and that trials needed to be carried out in people.
“Ivermectin is very widely used and seen as a safe drug. We need to figure out now whether the dosage you can use it at in humans will be effective – that’s the next step,” Dr Wagstaff said.
“In times when we’re having a global pandemic and there isn’t an approved treatment, if we had a compound that was already available around the world then that might help people sooner. Realistically it’s going to be a while before a vaccine is broadly available.
Although the mechanism by which Ivermectin works on the virus is not known, it is likely, based on its action in other viruses, that it works to stop the virus ‘dampening down’ the host cells’ ability to clear it, Dr Wagstaff said.
Royal Melbourne Hospital’s Dr Leon Caly, a Senior Medical Scientist at the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Doherty Institute where the experiments with live coronavirus were conducted, is the study’s first author.
“As the virologist who was part of the team who were first to isolate and share SARS-COV2 outside of China in January 2020, I am excited about the prospect of Ivermectin being used as a potential drug against COVID-19,” Dr Caly said.
Dr Wagstaff made a previous breakthrough finding on Ivermectin in 2012 when she identified the drug and its antiviral activity with Monash Biomedicine Discovery Institute’s Professor David Jans, also an author on this paper. Professor Jans and his team have been researching Ivermectin for more than 10 years with different viruses.
Dr Wagstaff and Professor Jans started investigating whether it worked on the SARS-CoV-2 virus as soon as the pandemic was known to have started.
The use of Ivermectin to combat COVID-19 would depend on the results of further pre-clinical testing and ultimately clinical trials, with funding urgently required to keep progressing the work, Dr Wagstaff said.
Read the full paper in Antiviral Research titled: The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro
“In times when we’re having a global pandemic and there isn’t an approved treatment, if we had a compound that was already available around the world then that might help people sooner. Realistically it’s going to be a while before a vaccine is broadly available.
Although the mechanism by which Ivermectin works on the virus is not known, it is likely, based on its action in other viruses, that it works to stop the virus ‘dampening down’ the host cells’ ability to clear it, Dr Wagstaff said.
Royal Melbourne Hospital’s Dr Leon Caly, a Senior Medical Scientist at the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Doherty Institute where the experiments with live coronavirus were conducted, is the study’s first author.
“As the virologist who was part of the team who were first to isolate and share SARS-COV2 outside of China in January 2020, I am excited about the prospect of Ivermectin being used as a potential drug against COVID-19,” Dr Caly said.
Dr Wagstaff made a previous breakthrough finding on Ivermectin in 2012 when she identified the drug and its antiviral activity with Monash Biomedicine Discovery Institute’s Professor David Jans, also an author on this paper. Professor Jans and his team have been researching Ivermectin for more than 10 years with different viruses.
Dr Wagstaff and Professor Jans started investigating whether it worked on the SARS-CoV-2 virus as soon as the pandemic was known to have started.
The use of Ivermectin to combat COVID-19 would depend on the results of further pre-clinical testing and ultimately clinical trials, with funding urgently required to keep progressing the work, Dr Wagstaff said.
Read the full paper in Antiviral Research titled: The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro
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About the Monash Biomedicine Discovery Institute at Monash University
Committed to making the discoveries that will relieve the future burden of disease, the newly established Monash Biomedicine Discovery Institute at Monash University brings together more than 120 internationally-renowned research teams. Our researchers are supported by world-class technology and infrastructure, and partner with industry, clinicians and researchers internationally to enhance lives through discovery.
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Source:
The
following article appeared in the Diário de Notícias ( Portugal ) today.
Read, and analyze carefully.I'm going to buy the medicine, just to prevent it, it is an approved medicine, and with no side effects in Portugal, in the treatment of parasites (scabies and lice), so it shouldn't be bad for your health.
I recommend having it at home, before it disappears from pharmacies.
The commercial name here in Portugal is Revectina (scientific name Ivermectina).
Again, read the entire story, and reflect before you buy.
Hugs to all my friends.
Ramiro Lopes Andrade
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